Experienced Scientist for de novo Peptide Design
You will join our Computational Drug Discovery team, driving innovation in peptide design and development of novel AI tools. We design and analyze large peptide datasets to accelerate Gubra’s pipeline and create next-generation drug discovery solutions.
About the Role In this role, your main responsibility will be to apply generative deep learning methods such as RFdiffusion and ColabDesign, and structure prediction frameworks such as AlphaFold to propose novel peptide binders. In addition to de novo design, you will be analyzing large experimental peptide datasets to propose design hypotheses of drug candidates.
This is a highly collaborative role, involving close interactions with chemistry, preformulation, and molecular pharmacology teams to design, predict, and optimize peptide drug candidates. Key Responsibilities Lead de novo design efforts using AlphaFold, ColabDesign, RFdiffusion and related tools Translate biochemistry and structural insights into peptide design hypothesis Analyze large in-house generated experimental peptide datasets to propose optimization strategies Develop and maintain Python-based pipelines and AI models for design and analysis of peptide data Qualifications PhD in biochemistry, bioinformatics, computational biology, or related field Experience from the pharma or biotech industry is highly desirable Experience with AI/ML in drug discovery Hands-on experience with AlphaFold and similar tools Strong understanding of structural biology and biochemical mechanisms (structure–function relationships, binding, stability, and activity) Proficiency in Python About Gubra & Your Team You will join 6 Scientists in the Computational Drug Discovery department at Gubra HQ in Hørsholm, Greater Copenhagen.
We work in a welcoming environment based on trust, helpfulness and a shared desire to break new ground, and we strongly believe that teamwork and knowledge sharing lead to better results and a more enjoyable workday. Contact and application Please apply using the ”Apply” button.The deadline is February 8, 2026. If you have any questions about the position, please contact Jens Christian Nielsen, Director, Computational Drug Discovery at jcn@gubra.dk. We look forward to receiving your application. About Gubra Gubra is an ambitious biotech company and contract research organisation (CRO) striving for excellence at all levels.
We insist on doing things efficiently – and often differently - to reach the results we aim for. Our vision is to become leaders in the fight for a more sustainable and healthier world. We do that by facilitating the discovery of new medicine, and by acting and inspiring others to fight the ongoing climate and biodiversity crises.
Gubra’s activities are focused on the early stages of drug development and are organised in two highly synergistic business areas: CRO Services and Discovery & Partnerships (D&P). We generate our revenue by performing research for life science companies as well as by partnering projects from our discovery and development pipeline.
Our therapeutic focus is within metabolic and fibrotic diseases, and we specialize in in vivo pharmacology, ex vivo assays, drug profiling, histology, stereology and whole brain and organ imaging. In addition, we offer a full palette of advanced transcriptomics.
Our ML/AI-driven peptide drug discovery platform streaMLine enables us to rapidly develop a peptide hit into a non-clinical candidate ready for development. Through a constant focus on high quality, scientific excellence, speed, and solid teamwork we have established ourselves as a highly professional and competent partner in the market.
People are our greatest asset, and our team consists of +290 employees. The mix of people from different cultures and educational backgrounds combined with our entrepreneurial mindset have greatly impacted our working environment, which is characterized by entrepreneurial drive, scientific curiosity, and teamwork – we join forces!
Apply Share in your network Deadline: Contact person: Jens Christian Nielsen Director Mail: jcn@gubra.dk Employment terms: Full time